Na+transport in cardiac myocytes; Implications for excitation-contraction coupling
نویسندگان
چکیده
منابع مشابه
Calmodulin regulation of excitation-contraction coupling in cardiac myocytes.
Calmodulin (CaM) as a ubiquitous Ca2+ sensor interacts with multiple key molecules involved in excitation-contraction (EC) coupling. In the present study, we report that adenoviral expression of a mutant CaM lacking all of its four Ca2+-binding sites, CaM(1-4), at a level 6.5-fold over endogenous CaM markedly increases the amplitude and abbreviates the decay time of Ca2+ transients and contract...
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It is well established that excitation contraction (EC) coupling in cardiac myocytes is mediated by the entry of calcium ions (Ca 2 ) from the bathing medium into the cell cytoplasm (Fabiato, 1985), which then triggers calcium-induced calcium release (CICR) from the sarcoplasmic reticulum (SR). More recently, it was proposed that a second, quite separate, EC-coupling process, mediated by an eff...
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gitudinal system of the SR, governing the Ca storage compartment with the highest recruitable amount of Ca in cardiac myocytes. The RyR are chemically coupled to L-type Ca channels via Ca, and a relatively small amount of Ca entering the cell via L-type Ca channels (depending on species or stimulation rate) activates a limited number of adjacent RyRs. This leads to Ca release from the SR, and a...
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Lysophosphoglyceride accumulation in ischemic myocardium has been implicated as a cause of arrhythmias. We examined the effects of lysophosphatidylcholine (LPC) in isolated guinea pig ventricular myocytes. In paced myocytes loaded with the Ca2+ indicator Indo-I-AM and studied at room temperature, 20 jiM LPC caused an initial positive inotropic effect followed by spontaneous automaticity, a decl...
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Atrial cardiomyocytes make an important contribution to the refilling of ventricles with blood, which enhances the subsequent ejection of blood from the heart. The dependence of cardiac function on the contribution of atria becomes increasingly important with age and exercise. We know much less about the calcium signals that link electrical depolarisation to contraction within atrial myocytes i...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2009
ISSN: 1521-6543,1521-6551
DOI: 10.1002/iub.163